Wig sctiutz



Patented a. 14, 1924.

UNITED STATES.

PATENT OFFICE.

LUDWIG TAUB, L'UDWIG SGH'U'TZ, AND IKU'IR'I. MEISENBURG, OF ELBERFELD, GEE MANY, ASSIGNORS TO FARBENFABBIKEN VORM. FRIEDR. BAYER AND 60., O1 LEVEBKUSEN, NEAR COLOGNE-ON-THE-RHINE, GERMANY.

HYPNOTIG.

No Drawing.

which has proved to'be a valuable hypnotic; an average dose being from A to gram. The process for its roduction consists in condensin crotylally alonic acid ester with urea in the presence of sodium alcoholate In order to illustrate the new process more fully the following example is given, the p-arts'being by weight: Y

255 arts of crotylallylmalonic acid ester are added to a solution of 46 parts of sodium in 800 parts of absolute alcohol. 60 parts of urea are added thereto and-the mixture is heated to boiling in a vessel provided with a reflux condenser during 5 hours. Subse- Application filed August 27, 1923. Serial No- 659,660.

' quently the alcohol is distilled ofi', water is added to the residue. The 1i uid is neutralized with dilute hydrochloric acid. The

crot lallylbarbituric acid precipitates from the iquid as an oil which soon solidifies.

Our new substance crystallizes from water in the sha e of white needles melting at 125126 and dissolves in alcohol. It possesses the property of forming-salts with many metals e. g. the alkali metals, or calcium, the hydrogen of the NH group replaced by the metal. It ma be, either used in the acid or salt form. he sodium salt is a white crystalline powder easily soluble in water.

\Ve claim As a new product crotylallylbarbituric acid of the formula:

C tic-EH I T 0135 l 0-NH c stallizing from water in the shape of w ite needles melting at 125-126 (3.; forming salts with alkali metals and calcium; and being a valuable hypnotic, substantially as described.

In testimony whereof we have hereunto set our hands. Y Y

LUDWIG TAUB. LUDWIG' soHUTz, KURT MEISENBURG.

being 

